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Aging Reversal BLOG


Dietary curcumin can protect against age-induced metabolic diseases.

While all organisms experience aging as a physiological process, type 2 diabetes and obesity are known to speed up biological aging. Research has already established links between dietary modifications and the prevention of obesity, type 2 diabetes and age-related hormonal changes.

A natural antioxidant called curcumin has been suggested to have therapeutic benefits in obesity-related conditions, such as increasing insulin sensitivity in obese rats. Cucumin is produced by the turmetic plant and has been extensively studied for its medicinal properties. A team of scientists from the National Institute on Aging (USA) and the University of Oklahoma, investigated the pleiotropic effects of dietary curcumin on insulin homeostasis in an elderly mice model of diet-induced obesity.

The study showed that supplementation with curcumin changed the activity of genes in the liver in obese mice, particularly those for insulin signaling and aging pathways. The study concluded that curcumin's extensive therapeutic potential might be utilized as a preventative measure against metabolic diseases such as diabetes.

Lee SJ, Chandrasekran P, Mazucanti CH, O'Connell JF, Egan JM, Kim Y. Dietary curcumin restores insulin homeostasis in diet-induced obese aged mice. Aging (Albany NY). 2022 Jan 11;14(1):225-239. doi: 10.18632/aging.203821. Epub 2022 Jan 11. PMID: 35017319; PMCID: PMC8791219.


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