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DETOXICATE - Cleanse & Energize is formulated to provide antioxidant support and neutralize free radicals and toxins, reduce inflammation and promote a healthy gastrointestinal system and bowel movement, and energy metabolism.
[DETOXICATE: -de- (Latin meaning “removal”, “reversal”), toxicate from -toxic- (Latin meaning poison)]
The average human is today exposed to around 700,000 toxic harmful substances each day. This exposure occurs through ingested foods and liquids, and skin exposure to fragrances, cleaning supplies, cosmetics, and other sources, and inhalation of toxins through polluted air and smoking. Our food is a major source of toxins and a few examples of such are pesticides, preservatives, residues from plastic packaging and heavy metals. By consuming fresh organic unprocessed food one can reduce the exposure to toxins
Our body performs detoxification continuously, and the liver, kidneys, intestinal system, lymphatic system, skin, and lungs are the key organs involved to build the body's detoxification pathways. Drinking enough water keeps your kidneys from having to work as hard to remove the toxins through urine, and water also removes toxins through other detox pathways, such as breathing and sweating. Our cells use antioxidants to protect from toxins known as free radicals. Consuming anti-oxidants can aid the body in fending against oxidative stress.
Supporting detoxification is only one of the numerous functions of the digestive tract. Through bowel movements, the digestive tract assists with toxin elimination. By consuming adequate fiber and caring for the billions of bacteria that reside in our bellies, we may maintain optimum gut health. When we consume fiber from whole-food plant-based sources, the digestive system is "bulked up", which aids in the elimination of waste.
Fiber does not only assist in reducing an excess of harmful microbes and toxins in the feces, but it also nourishes the healthy gut bacteria.
DETOXICATE is a total detox system that comprises multiple synergistically acting natural active ingredients that promote whole body detoxification.
Supports immune health, reduced blood pressure, digestive health, blood sugar regulation, and sexual health in men (110).
Supports immune health via enhanced antioxidant, antimicrobial, and anti-inflammatory properties (110).
Supports sex hormone health via decreased oxidative stress, increased luteinizing hormone (LH) production, reduced oxidative stress, reduced lipid peroxidation, enhanced activity antioxidant enzymes, increased blood flow, and recycling of testosterone receptors (110).
Acai Berry Extract
Supports antioxidant function, reduces blood pressure, supports kidney health, supports blood sugar regulation, supports cardiovascular health, and may combat against cancer (273,274,275).
Supports antioxidant function via polyphenolic components with high levels of anthocyanins (cyanidin-3-glucoside and cyanidin-3-rutinoside) (273, 274, 275).
May combat carcinogenesis via reduction of tumor cell proliferation, multiplicity and size of the tumors, increased anti-inflammatory capacity, increased antiproliferative activity, and increased pro-apoptotic activity (273).
Supports prostate health, cardiovascular support, antioxidant, anti-inflammatory, and chemopreventive properties against cancer (191,192, 193).
Combats inflammation via scavenging of free radicals and reduced oxidative damage of DNA. (191,192,193).
Combats carcinogenesis via carcinogen-metabolizing enzymes, apoptosis (cancer cell death), anti-proliferation, pro-differentiation, and anti-lipid peroxidation activities. (193).
Inhibits phosphorylation of anti-oncogenes such as p53 and Rb. It also inhibits G0/G1 and S-phase of the cell cycle (193).
Inulin (polysaccharides produced by many types of plants)
Supports digestive health, influencing lipid metabolism and regulates glucose and insulin levels (268,269).
Papaya Fruit Powder
Supports immune health and digestion.
Supports digestive health via enzymatic support of protein digestion (401, 402, 403, 404).
Hyssop Herb Powder
Supports respiratory health, digestive health, healthy detoxification, and may combat respiratory viruses (272).
Aloe ferox Powder
Supports digestive, cardiovascular, and metabolic health (270).
Supports reduction in total and low-density lipoprotein cholesterol (LDL-C) levels, glucose, and H1AC (270).
Supports cardiovascular health via reduced levels of fasting blood glucose, HbA1c, triglycerides, total cholesterol, LDL cholesterol, and increased HDL cholesterol (271).
Increases glucose absorption via high molecular weight enhancing glucose transport (271).
Reduces serum concentrations of cholesterol via reducing the absorption of cholesterol from the gut.
Supports antioxidant function, healthy detoxification, improved energy, cardiovascular health, and combats depression (265, 266).
Supports antioxidant function via high levels of carotenoids that product against DNA damage and scavenge free radicals (265).
Supports cardiovascular health via reduced cholesterol and triglyceride levels (265).
Supports detoxification via removal of methylmercury from the body (265).
Combats depression via reduced oxidative stress in the brain (266).
Black Walnut Hulls
Supports healthy detoxification (411).
Psyllium Husk Powder
Supports healthy digestion, gut microbiome, healthy bowl movements, blood sugar regulation, and natural appetite suppressant (269).
Increases stool water significant changes in microbiota in constipated patients (269).
Reduces constipation via reduction of the bacterial genus associated with hard stools (269).
Slippery Elm Bark Powder
Supports immune health, antioxidant function, and may combat liver carcinogenesis (276)
Supports antioxidant function
Combats liver carcinogenesis via y activating the mitochondrial pathway of apoptosis (cell death) of cancer cells (276).
1. Uses third-party independently tested ingredients that are made in the USA, GMP certified, and made in an FDA registered facility.
2. Uses high-quality nutraceuticals in an effective evidence-based and efficaciously dosed formula.
Other formulas on the market
1. Source cheap ingredients from heavily polluted soils. Even “organic” supplements not third-party tested have been removed by FDA due to high levels of heavy metals.
2. Uses cheap sources of nutraceuticals that contain high amounts of fillers, heavy metals, and in formulated without evidence-based dosages.
110. Hasani, H., Arab, A., Hadi, A., Pourmasoumi, M., Ghavami, A., & Miraghajani, M. (2019). Does ginger supplementation lower blood pressure? A systematic review and meta-analysis of clinical trials. Phytotherapy research : PTR, 33(6), 1639–1647. https://doi.org/10.1002/ptr.6362
273. Alessandra-Perini, J., Rodrigues-Baptista, K. C., Machado, D. E., Nasciutti, L. E., & Perini, J. A. (2018). Anticancer potential, molecular mechanisms and toxicity of Euterpe oleracea extract (açaí): A systematic review. PloS one, 13(7), e0200101. https://doi.org/10.1371/journal.pone.0200101
274. Yamaguchi, K. K., Pereira, L. F., Lamarão, C. V., Lima, E. S., & da Veiga-Junior, V. F. (2015). Amazon acai: chemistry and biological activities: a review. Food chemistry, 179, 137–151. https://doi.org/10.1016/j.foodchem.2015.01.055
275. de Moura, R. S., & Resende, Â. C. (2016). Cardiovascular and Metabolic Effects of Açaí, an Amazon Plant. Journal of cardiovascular pharmacology, 68(1), 19–26. https://doi.org/10.1097/FJC.0000000000000347
191. Chen, P., Zhang, W., Wang, X., Zhao, K., Negi, D. S., Zhuo, L., Qi, M., Wang, X., & Zhang, X. (2015). Lycopene and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis. Medicine, 94(33), e1260. https://doi.org/10.1097/MD.0000000000001260
192. Beynon, R. A., Richmond, R. C., Santos Ferreira, D. L., Ness, A. R., May, M., Smith, G. D., Vincent, E. E., Adams, C., Ala-Korpela, M., Würtz, P., Soidinsalo, S., Metcalfe, C., Donovan, J. L., Lane, A. J., Martin, R. M., ProtecT Study Group, & PRACTICAL consortium (2019). Investigating the effects of lycopene and green tea on the metabolome of men at risk of prostate cancer: The ProDiet randomised controlled trial. International journal of cancer, 144(8), 1918–1928. https://doi.org/10.1002/ijc.31929
193. Shanbhag V. K. (2016). Lycopene in cancer therapy. Journal of pharmacy & bioallied sciences, 8(2), 170–171. https://doi.org/10.4103/0975-7406.171740
268. Fan, C. H., Cao, J. H., & Zhang, F. C. (2016). The prebiotic inulin as a functional food - a review. European review for medical and pharmacological sciences, 20(15), 3262–3265.
269. Ahmed, W., & Rashid, S. (2019). Functional and therapeutic potential of inulin: A comprehensive review. Critical reviews in food science and nutrition, 59(1), 1–13. https://doi.org/10.1080/10408398.2017.1355775
272. Hyssop. (2018). In LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases.
270.Devaraj, S., Yimam, M., Brownell, L. A., Jialal, I., Singh, S., & Jia, Q. (2013). Effects of Aloe vera supplementation in subjects with prediabetes/metabolic syndrome. Metabolic syndrome and related disorders, 11(1), 35–40. https://doi.org/10.1089/met.2012.0066
271. Zhang, Y., Liu, W., Liu, D., Zhao, T., & Tian, H. (2016). Efficacy of Aloe Vera Supplementation on Prediabetes and Early Non-Treated Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients, 8(7), 388. https://doi.org/10.3390/nu8070388
265. Bito, T., Okumura, E., Fujishima, M., & Watanabe, F. (2020). Potential of Chlorella as a Dietary Supplement to Promote Human Health. Nutrients, 12(9), 2524. https://doi.org/10.3390/nu12092524
266. Panahi, Y., Badeli, R., Karami, G. R., Badeli, Z., & Sahebkar, A. (2015). A randomized controlled trial of 6-week Chlorella vulgaris supplementation in patients with major depressive disorder. Complementary therapies in medicine, 23(4), 598–602. https://doi.org/10.1016/j.ctim.2015.06.010
269.Jalanka, J., Major, G., Murray, K., Singh, G., Nowak, A., Kurtz, C., Silos-Santiago, I., Johnston, J. M., de Vos, W. M., & Spiller, R. (2019). The Effect of Psyllium Husk on Intestinal Microbiota in Constipated Patients and Healthy Controls. International journal of molecular sciences, 20(2), 433. https://doi.org/10.3390/ijms20020433
401. do Prado SBR, Minguzzi BT, Hoffmann C, Fabi JP. Modulation of human gut microbiota by dietary fibers from unripe and ripe papayas: Distinct polysaccharide degradation using a colonic in vitro fermentation model. Food Chem. 2021 Jun 30;348:129071
402. Kang YM, Kang HA, Cominguez DC, Kim SH, An HJ. Papain Ameliorates Lipid Accumulation and Inflammation in High-Fat Diet-Induced Obesity Mice and 3T3-L1 Adipocytes via AMPK Activation. Int J Mol Sci. 2021 Sep 14;22(18):9885. doi: 10.3390/ijms22189885. PMID: 34576066; PMCID: PMC8468764.
403. Abouzed TK, Sadek KM, Ayoub MM, Saleh EA, Nasr SM, El-Sayed YS, Shoukry M. Papaya extract upregulates the immune and antioxidants-related genes, and proteins expression in milk somatic cells of Friesian dairy cows. J Anim Physiol Anim Nutr (Berl). 2019 Mar;103(2):407-415. doi: 10.1111/jpn.13032. Epub 2018 Dec 3. PMID: 30511402.
404. Sy JBA, Hsu TC, Limaye A, Liu JR. Oral administration with a traditional fermented multi-fruit beverage modulates non-specific and antigen-specific immune responses in BALB/c mice. PLoS One. 2020 May 11;15(5):e0233047. doi: 10.1371/journal.pone.0233047. PMID: 32392269; PMCID: PMC7213741.
411. Meshkini A, Tahmasbi M. Antiplatelet Aggregation Activity of Walnut Hull Extract via Suppression of Reactive Oxygen Species Generation and Caspase Activation. J Acupunct Meridian Stud. 2017 Jun;10(3):193-203. doi: 10.1016/j.jams.2017.02.007. Epub 2017 Mar 6. PMID: 28712479.
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