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MUSCULERGIS - Pump & Build is a biological nitric oxide inducer that is formulated to improve exercise performance, increased blood flow to skeletal muscles, reduce the burn during intense workouts (decrease muscle ph. level) enhance your pump, and take your workouts to the next level!
[MUSCULERGIS: -muscul- (Latin meaning muscle), ergis from -ergon- (Greek meaning work)]
Numerous cellular activities, including vasodilation, the enlargement of blood vessels, depend on nitric oxide. More nutrients and oxygen are delivered to working muscles during exercise through wider blood arteries, which improves exercise performance.
The body creates nitric oxide, a chemical that promotes blood flow, naturally. Certain supplements work to enhance your blood's nitric oxide levels, which may increase blood flow to working muscles and shorten the amount of time it takes for you to become fatigued during an exercise. Athletes who used nitric oxide as a supplement in conjunction with their diet and recovery techniques also experienced better recovery because it sped up the body's excretion of lactate after exercise
Nitric oxide promotes blood flow to the brain and also plays roles in signaling between neurons and thereby likely to play a role in memory and cognition. Nitric oxide also plays a role in the metabolism of neurons.
MusculERGIS comprises multiple synergistically natural active ingredients that promote nitric oxide production and muscle growth.
L-Arginine AKG 2:1 Extract
Natural vasodilator precursor to increased nitric oxide levels (1).
Supports immune function by the maturation of the T cell (immune cell) receptor zeta (TCR) (2).
Improves exercise performance via increased stroke volume (blood flow) and increased nutrient delivery to exercising muscle (3).
Reduces arterial blood pressure, insulin resistance, and supports fat burning (4).
Supports cardiovascular health and exercise performance by increasing production of l-arginine (33, 34).
Increases nitric oxide production, improves exercise performance, and increases blood flow to exercising skeletal muscle (35).
Supports strength increases, exercise endurance, and recovery (34,35).
May reduce blood pressure by increasing vascular function (34).
Major B vitamin that supports cardiovascular health by inhibiting hepatic(liver) triglyceride synthesis, reducing very low-density lipoprotein (VLDL) secretion, and increasing HDL plasma concentrations (9).
Reduces conversion of VLDL into LDL proteins and serum lipoprotein concentrations in plasma (blood) (9).
Vital for regulation of gene expression, cell cycle progression, and DNA repair, and cell death (9).
Supports healthy inflammatory response via antioxidant and anti-apoptotic (prevention of cell death) properties (9).
Prevents pathologies(diseases) such as Pellagra and reduces prevalence of nervous anorexia, cancer, and chrome’s disease (10, 11).
Supports cognitive health by reducing age related decline of NAD+, increasing quinolinic acid and reducing neuroinflammation (8, 9).
Increased niacin associated NAD+ levels have been shown to increase neurotransmission, learning and memory (9).
Niacin reduces the prevalence of neurodegenerative pathologies by preventing mitochondrial dysfunction (9).
Improves exercise performance, increases nutrient delivery to exercising muscle, and reduces lactate associated neurological exercise fatigue (15).
Reduces carnosine (muscle acidity) levels and acts as an intramuscular ph buffer (15).
Reduces lactate “burn” associated fatigue during extreme exercise (15).
Supports bone health, muscle function, and cardiovascular health (36,37).
Regulates processes of bone resorption, mineralization, and fracture repair (36,37).
Increases the effect of physical exercise on bone mineral acquisition in the period preceding puberty (36,37).
Prevents the development of preeclampsia (36,37).
1. Uses third party independently tested ingredients that are made in the USA, GMP certified, and made in an FDA registered facility.
2. Uses high quality nutraceuticals in an effective evidence based and efficaciously dosed formula.
Other formulas on the market
1. Source cheap ingredients from heavily polluted soils. Even “organic” supplements not third party tested have been removed by FDA due to high levels of heavy metals.
2. Uses cheap sources of nutraceuticals that contain high amounts of fillers, heavy metals, and in formulated without evidence-based dosages.
1. Sureda, A., & Pons, A. (2012). Arginine and citrulline supplementation in sports and exercise: ergogenic nutrients?. Medicine and sport science, 59, 18–28. https://doi.org/10.1159/000341937
2. Szefel, J., Danielak, A., & Kruszewski, W. J. (2019). Metabolic pathways of L-arginine and therapeutic consequences in tumors. Advances in medical sciences, 64(1), 104–110. https://doi.org/10.1016/j.advms.2018.08.018
3. Rodrigues-Krause, J., Krause, M., Rocha, I., Umpierre, D., & Fayh, A. (2018). Association of l-Arginine Supplementation with Markers of Endothelial Function in Patients with Cardiovascular or Metabolic Disorders: A Systematic Review and Meta-Analysis. Nutrients, 11(1), 15. https://doi.org/10.3390/nu11010015
4. Hu, S., Han, M., Rezaei, A., Li, D., Wu, G., & Ma, X. (2017). L-Arginine Modulates Glucose and Lipid Metabolism in Obesity and Diabetes. Current protein & peptide science, 18(6), 599–608. https://doi.org/10.2174/1389203717666160627074017
33. Barkhidarian, B., Khorshidi, M., Shab-Bidar, S., & Hashemi, B. (2019). Effects of L-citrulline supplementation on blood pressure: A systematic review and meta-analysis. Avicenna journal of phytomedicine, 9(1), 10–20.
34. Figueroa, A., Wong, A., Jaime, S. J., & Gonzales, J. U. (2017). Influence of L-citrulline and watermelon supplementation on vascular function and exercise performance. Current opinion in clinical nutrition and metabolic care, 20(1), 92–98. https://doi.org/10.1097/MCO.0000000000000340
35. Bahri, S., Zerrouk, N., Aussel, C., Moinard, C., Crenn, P., Curis, E., Chaumeil, J. C., Cynober, L., & Sfar, S. (2013). Citrulline: from metabolism to therapeutic use. Nutrition (Burbank, Los Angeles County, Calif.), 29(3), 479–484. https://doi.org/10.1016/j.nut.2012.07.002
8. Gasperi, V., Sibilano, M., Savini, I., & Catani, M. V. (2019). Niacin in the Central Nervous System: An Update of Biological Aspects and Clinical Applications. International journal of molecular sciences, 20(4), 974. https://doi.org/10.3390/ijms20040974
9. Gentilcore D. (2016). Louis Sambon and the Clash of Pellagra Etiologies in Italy and the United States, 1905-14. Journal of the history of medicine and allied sciences, 71(1), 19–42. https://doi.org/10.1093/jhmas/jrv002
10. Kirkland J. B. (2009). Niacin status and treatment-related leukemogenesis. Molecular cancer therapeutics, 8(4), 725–732. https://doi.org/10.1158/1535-7163.MCT-09-0042
11. Hoskin, P., Rojas, A., & Saunders, M. (2009). Accelerated radiotherapy, carbogen, and nicotinamide (ARCON) in the treatment of advanced bladder cancer: mature results of a Phase II nonrandomized study. International journal of radiation oncology, biology, physics, 73(5), 1425–1431. https://doi.org/10.1016/j.ijrobp.2008.06.1950
15. Trexler, E. T., Smith-Ryan, A. E., Stout, J. R., Hoffman, J. R., Wilborn, C. D., Sale, C., Kreider, R. B., Jäger, R., Earnest, C. P., Bannock, L., Campbell, B., Kalman, D., Ziegenfuss, T. N., & Antonio, J. (2015). International society of sports nutrition position stand: Beta-Alanine. Journal of the International Society of Sports Nutrition, 12, 30. https://doi.org/10.1186/s12970-015-0090-y
36. Khaing, W., Vallibhakara, S. A., Tantrakul, V., Vallibhakara, O., Rattanasiri, S., McEvoy, M., Attia, J., & Thakkinstian, A. (2017). Calcium and Vitamin D Supplementation for Prevention of Preeclampsia: A Systematic Review and Network Meta-Analysis. Nutrients, 9(10), 1141. https://doi.org/10.3390/nu9101141
37. Courteix, D., Jaffré, C., Lespessailles, E., & Benhamou, L. (2005). Cumulative effects of calcium supplementation and physical activity on bone accretion in premenarchal children: a double-blind randomised placebo-controlled trial. International journal of sports medicine, 26(5), 332–338. https://doi.org/10.1055/s-2004-821040
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