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B12 VITAGEN - Biosynthesis vitamin B12 formula is made with the highest quality B12 vitamin, along with a comprehensive vitamin B complex, to support increased energy metabolism, nervous system health, growth of hair, skin and nails, and antioxidant activity.
[B12 VITAGEN: B12 from Vitamin B12; -vit- (Latin meaning “life”); -gen- (Greek/Latin meaning “produced”, “comes from”)]
Vitamin B12 (cobalamin), and other B vitamins, is essential for proper functioning of our bodies. It supports the synthesis of DNA, promotes a healthy brain and nervous system, the production of healthy hair, skin and nails. Vitamin B12 is naturally found in meat, fish, and dairy products.
Vitamin B deficiency can result in acne, rashes, dry, flaky skin, cracked lips, and wrinkles. Additionally, it might increase your skin's sensitivity to the sun, cosmetics, and other potential irritants, which can result in rashes and redness. Vitamin B may promote production of healthy new skin cells, and niacinamide, often known as vitamin B-3, may slow down skin aging.
Vitamin B has also many beneficial functions for athletes because they are involved in numerous metabolic processes that are directly related to exercise performance, such as energy synthesis, red blood cell formation, and muscle growth and repair.
B12 VITAGEN Vitamin B12 Formula comprises key members of the vitamin B complex with a broad range of health benefits.
Aids as an antioxidant via direct scavenging of reactive oxygen species (inflammation), preserving l-glutathione levels (master antioxidant), and reducing oxidative stress (51).
May prevent vitamin B-12 deficiency diseases such as anemia, neurodegenerative disease, cardiovascular disease, and osteoporosis (52, 53).
Supports conversion and activation of other B vitamins, red blood cell production and serves as a cofactor for both glucose and fat metabolism (energy production) (92,93).
Major B vitamin that supports cardiovascular health by inhibiting hepatic(liver) triglyceride synthesis, reducing very-low-density lipoprotein (VLDL) secretion, and increasing HDL plasma concentrations (9).
Reduces conversion of VLDL into LDL proteins and serum lipoprotein concentrations in plasma (blood) (9).
Vital for regulation of gene expression, cell cycle progression, and DNA repair, and cell death (9).
Supports healthy inflammatory response via antioxidant and anti-apoptotic (prevention of cell death) properties (9).
Prevents pathologies(diseases) such as Pellagra and reduces prevalence of nervous anorexia, cancer, and crohn's disease (10, 11).
Supports cognitive health by reducing age-related decline of NAD+, increasing quinolinic acid and reducing neuroinflammation (8, 9).
Increased niacin associated NAD+ levels have been shown to increase neurotransmission, learning and memory (8, 9).
Niacin reduces the prevalence of neurodegenerative pathologies by preventing mitochondrial dysfunction (9).
Supports energy production, cell growth, cell repair, cognitive function, increased hippocampal volume (memory), and optimized bioenergetics (burning of carbohydrates, fat, and protein) (96).
Serves as a cofactor in more than 150 enzymatic reactions associated in blood sugar regulation, immunity, cardiovascular function, neuronal health, metabolic, and digestive health (38, 40).
Reduces plasma glucose (blood sugar levels) via by inhibiting the activity of small-intestinal α-glucosidases (enzymes associated with glucose metabolism) (39).
Functions as an antioxidant by counteracting the formation of reactive oxygen species (inflammatory markers) and advanced glycation end-products (38,40).
May support blood sugar regulation in women with gestational diabetes (40).
Cofactor for enzymes involved in DNA metabolism (40).
1. Uses third party independently tested ingredients that are made in the USA, GMP certified, and made in an FDA registered facility.
2. Uses high quality nutraceuticals in an effective evidence based and efficaciously dosed formula.
Other formulas on the market
1. Source cheap ingredients from heavily polluted soils. Even “organic” supplements not third party tested have been removed by FDA due to high levels of heavy metals.
2. Uses cheap sources of nutraceuticals that contain high amounts of fillers, heavy metals, and in formulated without evidence based dosages.
51. van de Lagemaat, E. E., de Groot, L., & van den Heuvel, E. (2019). Vitamin B12 in Relation to Oxidative Stress: A Systematic Review. Nutrients, 11(2), 482. https://doi.org/10.3390/nu11020482
52. Romain, M., Sviri, S., Linton, D. M., Stav, I., & van Heerden, P. V. (2016). The role of Vitamin B12 in the critically ill--a review. Anaesthesia and intensive care, 44(4), 447–452. https://doi.org/10.1177/0310057X1604400410
53. Shipton, M. J., & Thachil, J. (2015). Vitamin B12 deficiency - A 21st century perspective . Clinical medicine (London, England), 15(2), 145–150. https://doi.org/10.7861/clinmedicine.15-2-145.
92. Thakur, K., Tomar, S. K., Singh, A. K., Mandal, S., & Arora, S. (2017). Riboflavin and health: A review of recent human research. Critical reviews in food science and nutrition, 57(17), 3650–3660. https://doi.org/10.1080/10408398.2016.1145104
93. Suwannasom, N., Kao, I., Pruß, A., Georgieva, R., & Bäumler, H. (2020). Riboflavin: The Health Benefits of a Forgotten Natural Vitamin. International journal of molecular sciences, 21(3), 950. https://doi.org/10.3390/ijms21030950
8. Gasperi, V., Sibilano, M., Savini, I., & Catani, M. V. (2019). Niacin in the Central Nervous System: An Update of Biological Aspects and Clinical Applications. International journal of molecular sciences, 20(4), 974. https://doi.org/10.3390/ijms20040974
9. Gentilcore D. (2016). Louis Sambon and the Clash of Pellagra Etiologies in Italy and the United States, 1905-14. Journal of the history of medicine and allied sciences, 71(1), 19–42. https://doi.org/10.1093/jhmas/jrv002
10. Kirkland J. B. (2009). Niacin status and treatment-related leukemogenesis. Molecular cancer therapeutics, 8(4), 725–732. https://doi.org/10.1158/1535-7163.MCT-09-0042
11. Hoskin, P., Rojas, A., & Saunders, M. (2009). Accelerated radiotherapy, carbogen, and nicotinamide (ARCON) in the treatment of advanced bladder cancer: mature results of a Phase II nonrandomized study. International journal of radiation oncology, biology, physics, 73(5), 1425–1431. https://doi.org/10.1016/j.ijrobp.2008.06.1950
96. Ragaller, V., Lebzien, P., Südekum, K. H., Hüther, L., & Flachowsky, G. (2011). Pantothenic acid in ruminant nutrition: a review. Journal of animal physiology and animal nutrition, 95(1), 6–16. https://doi.org/10.1111/j.1439-0396.2010.01004.x
38. Ueland, P. M., McCann, A., Midttun, Ø., & Ulvik, A. (2017). Inflammation, vitamin B6 and related pathways. Molecular aspects of medicine, 53, 10–27. https://doi.org/10.1016/j.mam.2016.08.001
39. Bird R. P. (2018). The Emerging Role of Vitamin B6 in Inflammation and Carcinogenesis. Advances in food and nutrition research, 83, 151–194. https://doi.org/10.1016/bs.afnr.2017.11.004
40. Mascolo, E., & Vernì, F. (2020). Vitamin B6 and Diabetes: Relationship and Molecular Mechanisms. International journal of molecular sciences, 21(10), 3669. https://doi.org/10.3390/ijms21103669
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