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PANDEFENSO - Immunity - is a total immune defense formula that is designed to support immune health, cardiovascular health, skin health, and energy production. Our formula uses over 1,000mg of Elderberry, 1500 IU of Vitamin D, whole food Vitamin C, 11 mg of Zinc, flavored with stevia and pink Himalayan salt in an effective evidence based and efficaciously dosed formula.
[PANDEFENSO: -pan- (Greek meaning “all”); defenso from -defendere- (Latin meaning “to defend”)]
We are continuously exposed to millions, if not billions, of microbes in our environment, and approximately1,400 of these are known human pathogens (including viruses, bacteria, fungi and parasites) that can cause a variety of infections, many of which are incurable and even deadly. Global transport and population growth has made it easier than ever for these microbes to be rapidly spread across our world.
Research has shown that a handshake involves the transfer of an average of 124 million bacteria from one person to another, and a kiss will transfer about 80 million. A keyboard can have as many as 8000 bacteria. The good news is that we can continue shaking hands, kissing and using computers without fear of infections when our immune system is functioning well.
Our immune system comprises a variety of defense molecules and mechanisms that ward off microbes and protect us from infections and cancers. A weak or dysregulated immune system will not only expose us to deadly infections, but also chronic inflammation and accelerated aging.
PANDEFENSO has been designed to boost defense capabilities by stimulating both innate and adaptive components of our immune system through the synergistic action of several natural ingredients:
Vitamin C (Acerola Cherry)
Supports immune, cardiovascular, skin, cognitive, fat burning, and digestive health (97, 98).
Supports immune health via increased oxidant, free radical scavenging, and fueling neutrophilic (immune cell) activity in chemotaxis, phagocytosis, and microbial killing (97,98).
Supports fat burning by increasing carnitine biosynthesis (molecule required for mitochondrial fatty acid oxidation) (97,98).
Supports accelerate bone healing after a fracture, increase type I collagen synthesis, and reduce oxidative stress (inflammation) (98).
Supports reduced DNA damage in the kidney, liver, and bone marrow (318).
Vitamin B-12 (Methylcobalamin)
Metabolically active, methylated form of Vitamin B12 needed for proper DNA synthesis, folate cycle function, energy production, cognitive function, and immune health (51,53).
Aids as an antioxidant via direct scavenging of reactive oxygen species (inflammation), preserving l-glutathione levels (master antioxidant), and reducing oxidative stress (51).
May prevent vitamin B-12 deficiency diseases such as anemia, neurodegenerative disease, cardiovascular disease, and osteoporosis (52, 53).
Supports immune function, skin health, cognitive function, and vision (172,173).
Supports stimulation of the innate and adaptive immune system (172,173).
Supports the activation of lymphocytes and activation of innate and T cell mediated immunity (172,173).
Supports cognitive function by modulation of neuronal signaling in areas of the brain associated with memory and learning (hippocampus) (172,173).
Supports antioxidant function, cardiovascular health, combats respiratory infections, and aids as antiviral agent (231,232,233,234).
Supports antioxidant function due to polyphenolic content, increased free radical scavenging ability, and reduced inflammatory cytokines (231,232,233)
May support antiviral activity against pathogens via flavonoids that bind to and prevent H1N1-type IV infection (234).
Supports antimicrobial effects via combating bacteria that cause upper respiratory tract infections (Gram-positive bacteria Streptococcus pyogenes and group C and G Streptococci) (234).
Magnesium (di magnesium malate)
Supports optimal nerve function, muscle contractions, cardiovascular, bone health, and decreased anxiety (90,91).
Supports biological reactions such as ATP fueled reactions and pancreatic insulin secretion (90,91).
Supports reduction systolic blood pressure, fasting glucose, triglycerides, and healthy HDL levels (90,91).
Reduces peripheral cortisol levels in the central nervous system and supports relaxation and decreased anxiety (90,91).
Supports bone health, muscle function, and cardiovascular health (36,37).
Regulates processes of bone resorption, mineralization, and fracture repair (36,37).
Increases the effect of physical exercise on bone mineral acquisition in the period preceding puberty (36,37).
Prevents the development of preeclampsia (36,37).
Supports exercise performance, immune health, muscle growth, optimal bone health, hormonal health, immune function, increased sexual health, cardiovascular health, glucose tolerance, strength, and positive mood (77,78,79).
Supports hormonal health via high amounts of vitamin D receptor (VDR) activity in hormone based negative feedback loop reactions (77,78).
Supports cardiovascular health via improved absorption of calcium, reduced atherosclerotic activity, stimulating cardiomyocytes, and improved vascular health (77,78).
Supports exercise performance via reduced exercise associated inflammation and muscle damage (77,78).
Supports sexual health via increased activity of Vitamin D receptor activity of testosterone production (79).
Supports immune function via decreases of inflammatory cytokines and aiding immune cells (77,78).
Supports joint health via regulating calcium and phosphorus and bone remodeling along with other calcium-regulating actions (77,78).
Supports reduced blood pressure in hypertensive patients and improves hydration in individuals with low potassium levels (262).
1. Uses third party independently tested ingredients that are made in the USA, GMP certified, and made in an FDA registered facility.
2. Uses over 1,000mg of Elderberry, 1500 IU of Vitamin D, whole food vitamin C, 11 mg of Zinc, flavored with stevia and pink Himalayan salt in an effective evidence based and efficaciously dosed formula.
Other formulas on the market
1. Source cheap ingredients from heavily polluted soils. Even “organic” supplements not third party tested have been removed by FDA due to high levels of heavy metals.
2. Uses cheap and low dose formulas of elderberry, vitamin c, vitamin D, Zinc, and magnesium that contain high amounts of fillers, heavy metals, and is formulated without evidence-based dosages.
97. Carr, A. C., & Maggini, S. (2017). Vitamin C and Immune Function. Nutrients, 9(11), 1211. https://doi.org/10.3390/nu9111211
98. DePhillipo, N. N., Aman, Z. S., Kennedy, M. I., Begley, J. P., Moatshe, G., & LaPrade, R. F. (2018). Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review. Orthopaedic journal of sports medicine, 6(10), 2325967118804544. https://doi.org/10.1177/2325967118804544
51. van de Lagemaat, E. E., de Groot, L., & van den Heuvel, E. (2019). Vitamin B12 in Relation to Oxidative Stress: A Systematic Review. Nutrients, 11(2), 482. https://doi.org/10.3390/nu11020482
52. Romain, M., Sviri, S., Linton, D. M., Stav, I., & van Heerden, P. V. (2016). The role of Vitamin B12 in the critically ill--a review. Anaesthesia and intensive care, 44(4), 447–452. https://doi.org/10.1177/0310057X1604400410
53. Shipton, M. J., & Thachil, J. (2015). Vitamin B12 deficiency - A 21st century perspective . Clinical medicine (London, England), 15(2), 145–150. https://doi.org/10.7861/clinmedicine.15-2-145
172. Maywald, M., Wessels, I., & Rink, L. (2017). Zinc Signals and Immunity. International journal of molecular sciences, 18(10), 2222. https://doi.org/10.3390/ijms18102222
173. Wessels, I., Rolles, B., & Rink, L. (2020). The Potential Impact of Zinc Supplementation on COVID-19 Pathogenesis. Frontiers in immunology, 11, 1712. https://doi.org/10.3389/fimmu.2020.01712
231. Ulbricht, C., Basch, E., Cheung, L., Goldberg, H., Hammerness, P., Isaac, R., Khalsa, K. P., Romm, A., Rychlik, I., Varghese, M., Weissner, W., Windsor, R. C., & Wortley, J. (2014). An evidence-based systematic review of elderberry and elderflower (Sambucus nigra) by the Natural Standard Research Collaboration. Journal of dietary supplements, 11(1), 80–120. https://doi.org/10.3109/19390211.2013.859852
232. Hawkins, J., Baker, C., Cherry, L., & Dunne, E. (2019). Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials. Complementary therapies in medicine, 42, 361–365. https://doi.org/10.1016/j.ctim.2018.12.004
233.Tiralongo, E., Wee, S. S., & Lea, R. A. (2016). Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial. Nutrients, 8(4), 182. https://doi.org/10.3390/nu8040182
234.Krawitz, C., Mraheil, M. A., Stein, M., Imirzalioglu, C., Domann, E., Pleschka, S., & Hain, T. (2011). Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses. BMC complementary and alternative medicine, 11, 16. https://doi.org/10.1186/1472-6882-11-16
90. Boyle, N. B., Lawton, C., & Dye, L. (2017). The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients, 9(5), 429. https://doi.org/10.3390/nu9050429
91. Verma, H., & Garg, R. (2017). Effect of magnesium supplementation on type 2 diabetes associated cardiovascular risk factors: a systematic review and meta-analysis. Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 30(5), 621–633. https://doi.org/10.1111/jhn.12454
36. Khaing, W., Vallibhakara, S. A., Tantrakul, V., Vallibhakara, O., Rattanasiri, S., McEvoy, M., Attia, J., & Thakkinstian, A. (2017). Calcium and Vitamin D Supplementation for Prevention of Preeclampsia: A Systematic Review and Network Meta-Analysis. Nutrients, 9(10), 1141. https://doi.org/10.3390/nu9101141
37. Courteix, D., Jaffré, C., Lespessailles, E., & Benhamou, L. (2005). Cumulative effects of calcium supplementation and physical activity on bone accretion in premenarchal children: a double-blind randomised placebo-controlled trial. International journal of sports medicine, 26(5), 332–338. https://doi.org/10.1055/s-2004-821040
77. Chang, S. W., & Lee, H. C. (2019). Vitamin D and health - The missing vitamin in humans. Pediatrics and neonatology, 60(3), 237–244. https://doi.org/10.1016/j.pedneo.2019.04.007
78. Zhang, Y., Fang, F., Tang, J., Jia, L., Feng, Y., Xu, P., & Faramand, A. (2019). Association between vitamin D supplementation and mortality: systematic review and meta-analysis. BMJ (Clinical research ed.), 366, l4673. https://doi.org/10.1136/bmj.l4673
79. Pilz, S., Frisch, S., Koertke, H., Kuhn, J., Dreier, J., Obermayer-Pietsch, B., Wehr, E., & Zittermann, A. (2011). Effect of vitamin D supplementation on testosterone levels in men. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 43(3), 223–225. https://doi.org/10.1055/s-0030-1269854
262. Filippini, T., Violi, F., D'Amico, R., & Vinceti, M. (2017). The effect of potassium supplementation on blood pressure in hypertensive subjects: A systematic review and meta-analysis. International journal of cardiology, 230, 127–135. https://doi.org/10.1016/j.ijcard.2016.12.048
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