Endogenous production and tissue levels of coenzyme Q10 (CoQ10) appear to decrease with aging for unknown reasons. When CoQ10 levels are low, the mitochondrial activity is compromised resulting in an increase in oxidativestress molecules. Additionally, the Sirtuin 1 and Sirtuin 3 enzymes which are thought to be important predictors of life expectancy, can be expected to decline in response to CoQ10 deficiency. DiNicolantonio and scientist colleagues at the University of Missouri-Kansas City believe that the therapeutic benefits of CoQ10 supplementation found in heart failure, hypertension, non-alcoholic fatty liver disease, metabolic syndrome, and periodontal disease can be explained by understanding the functions of Sirtuins in modulating cellular activity. Therefore, counteracting CoQ10 deficiency adds to the growing list of actions that may promote health and longevity.
DiNicolantonio JJ, McCarty MF, O'Keefe JH. Coenzyme Q10 deficiency can be expected to compromise Sirt1 activity. Open Heart. 2022 Mar;9(1):e001927. doi: 10.1136/openhrt-2021-001927. PMID: 35296520; PMCID: PMC8928362.